At the simplest, edit the Engine portion of your server.xml file to look like this:
<Engine name=”Catalina” defaultHost=”ren”>
<Host name=”ren” appBase=”renapps”/>
<Host name=”stimpy” appBase=”stimpyapps”/>
</Engine>
Note that the directory structures under the appBase for each host should not overlap each other.
Consult the configuration documentation for other attributes of the Engine and Host elements.